Introduction: Since the isolation of Helicobacter pylori in 1983, much evidence has accumulated to show its important role in the pathogenesis of chronic gastritis, peptic ulcer and gastric cancer. During the multistep process of carcinogenesis, the regulation of cell proliferation and apoptosis are suggested to be disturbed, with enhanced cell turnover.Aim of The Study: To determine the influence of H. pylori infection on gastric cells proliferation and apoptosis in the pediatric age group.Methodology: The study included 30 pediatric patients undergoing upper GI endoscopy for different indications. Patients were tested for the presence of infection using rapid urease testing and histopathologic examination of their gastric antral biopsies, obtained during the course of endoscopy. Staining of the biopsies was done using H&E and Giemsa stains. In addition, Feulgen nucleal reaction and KI-67 monoclonal antibody were used for detection of apoptotic events and proliferating cells respectively.Results: Out of the 30 studied patients, 25 proved to be +ve for H. pylori (83.3%). On comparing the H. pylori +ve patients to the –ve ones, we found that both the PI% and AI/PI ratio were significantly related to H. pylori status. In addition, both parameters, together with AI% were found to be significantly related to the degree of activity detected in the biospy specimens in the H. pylori +ve patients. However, no statistically significant relationship could be illustrated between any of them and the clinical symptoms and complications that could be attributed to the infection.Conclusion: There is enhanced cell turnover in H. pylori chronic gastritis, which is suggested to play an important role in gastric carcinogenesis.