Abstract: Background: An ideal fluid for resuscitation of hypovolemic shock should improve tissue and microvascular perfusion; has a minimal adverse reaction, available, and not costly. It should also have minimal contraindications that can be started even by paramedical personnel’s during transfer from the scene of trauma. None of the known resuscitation fluids can satisfy the whole criteria. In our study we compared a newly introduced hypertonic saline 7.5% versus the traditional 0.9% normal saline in the resuscitation of calculated induced hypovolemic shock in cats and clinically in the critical trauma patients with hypovolemic hemorrhagic shock for surgical intervention. Patients and Methods: Eighty adult patients, with a trauma score of less than 13 fulfilling other inclusion criteria of hypovolemic shock, and all, were candidates for surgery were randomly divided into two equal groups: Group I: 40 patients received (NS) 10 mL/kg/hour normal saline 0.9% solution. Group II: the other 40 patients received (HTS) 7.5% NaCl solution with an average total volume 2-4 ml/kg, as well as an average of 5 mL/kg/hour (NS). In both groups further fluid and blood therapy will be managed according to hemodynamic status and hematological analysis. Hemodynamic, hematological picture, blood gas analysis, osmolarity, blood electrolytes and blood lactic acid were estimated pre, intra and postoperatively.Results: In patients resuscitated with (HTS) there was a rapid rise of systolic blood pressure; drop of diastolic pressure with elevation of C.V.P. than those resuscitated with (NS). Pulse rate and core temperature returns to normal in (HTS) group and serum Na+ and Cl- rose while serum K+ showed a significant drop. Gasometry revealed a decrease in pH and HCO- in (HTS) group. Whereas, serum lactate decreased. Hemoglobin and hematocrit were relatively higher in-group II than those patients of group I. Conclusion: Hypertonic saline was proved to have a rapid restorative effect over the systolic blood pressure of hypovolemic shocked patient; meanwhile, diastolic blood pressure showed some drop. The net result is much improvement of perfusion pressure of shocked patients.