The aim of this review is to study the effect of the different Posterior Chamber Intraocular Lens designs and materials on the evolution, pathogenesis and progression of Posterior Capsule Opacification. We found that an almost typical IOL design is one that possesses a biconvex optic with a large diameter 5.0 – 6.0 mm, rounded in shape and a sharp square shaped edge. The haptics of a short “C” shaped configuration, 12-12.5 mm in diameter. As for the IOL material, the foldable Acrylic, Hydrogel and the new Collamer IOL showed a better performance inside the eye regarding postoperative PCO when compared to Silicone and PMMA IOLs. Other physical and pharmacological methods are still under study for the prophylaxis of PCO.