Non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin have been widely used clinically as anti inflammatory, analgesic agent, but it has been documented that they produce gastrointestinal injury. Paracetamol is analgesic, antipyretic but differs from other non steroidal anti-inflammatory drugs (NSAIDs) in having no anti-inflammatory activity. The study used 100 male adult albino rats; their weigh ranged 200 and 250. They were divided into four groups. Indomethacin was found to cause severe and dramatic injury to the rat gastric mucosa. When paracetamol given 30 minutes before indomethacin intake, it produced obvious protection of the gastric mucosa against the severe injurious effect produced by indomethacin.