Pulmonary hypertension (PHT) is a common complication of Sickle Cell Disease (SCD) patients associated with high mortality. Early detection and intervention may potentially reverse this life-threatening complication and improve survival in SCD patients.The prevalence of PHT in the pediatric SCD population is not known despite its high prevalence in adult patients. The aim of the current study was to determine the prevalence of PHT in children and adolescents with SCD and to evaluate the risk factors.Fifty SCD children were screened for PHT, which was defined as a mean pulmonary artery pressure (PAP) above 25 mm Hg corresponding to a peak tricuspid regurgitant jet velocity (TRV) ≥ 2.5 m/s. Nine (18%) SCD patients had increased PAP (i.e., TRV ≥ 2.5 m/s).Significant correlation was found between TRV elevation and elevated systolic blood pressure, recurrent infections, repeated vasooclusive crisis, increase amount of blood transfusion, splenectomy, low hemoglobin level, high total leucocytic count, increased platelet count, high reticulocytic count, high ALT, high T.BIL, high ferritin and high LDH. The LDH and HbS% were the identifiable independent risk factors for development of PHT in SCD patients with p-value = 0.005 and 0.050 respectively. Also, patients with PHT had splenectomy 5.455 times higher than patients without PHT, with 95%CI 25.662 – 1.159 and p-value = 0.035, was found as identifiable independent risk factor. Echocardiography is useful to screen SCD patients for PHT in those at risk. Further studies are needed to clarify the prevalence and mechanism of PHT in pediatric patients with SCD.