Vascular endothelial growth factor and its receptors may play a pivotal role in the altered function of PE. Many polymorphisms of the VEGF gene have been identified; a few of them have been correlated with variation in VEGF protein production. The aim of this work is to evaluate whether the serum level of soluble VEGF 1 as well as VEGF 936 C/T gene polymorphism are associated with increased risk of preeclampsia. Analysis of serum soluble VEGF-R1 by ELISA and Deoxyribonucleic acid analysis for VEGF gene polymorphism (936C/T) using PCR followed by RFLP was done. a highly statistically significant difference was found between cases and control groups as regards VEGF-R1 serum levels and there was a significant difference in VEGF 936 C/T genotypes between cases and control groups.