Background and Aim: Cirrhosis is the cause of thousand deaths per year. This study aimed to determine the relationship between laminin and chromogranin-A levels and severity of liver dysfunction in liver cirrhosis.Subjects and Methods: The study included 30 patients with liver cirrhosis and 20 healthy subjects serving as control. Laminin and CgA were measured with an enzyme-linked immunosorbent assay.Results: Laminin and CgA levels were significantly higher in cirrhotic patients than in controls. On using the receiver operator curve (ROC) to improve the specificity and sensitivity of laminin, the cutoff value of 242 ng/ml yielded a sensitivity and specificity of 96.7% and 75%, respectively. The diagnostic sensitivity of CgA at a cutoff of 75.6 ng/dl was 100% and the specificity was 85%. Combined use of AFP with laminin and CgA led to improving the specificity of serological diagnosis of liver cirrhosis up to 90% and 95% respectively.Conclusion: Combination of laminin and CgA as non invasive markers of liver cirrhosis would improve the diagnostic power of these markers.