Modern studies of obesity strongly indicate that it is a multifactorial problem. The effect of obesity on skin has received minimal attention, inspite of the profound impact of obesity on clinical dermatology.Obesity is related to a number of significant changes in skin physiology, including effects on skin barrier function, sebaceous glands and sebum production, sweat glands, lymphatics, collagen structure and function, wound healing, microcirculation and macrocirculation, and subcutaneous fat.Obesity is implicated in a wide spectrum of dermatological diseases, including acanthosis nigricans, acrochordons (skin tags), keratosis pilaris, hyperandrogenism and hirsutism, striae distensae, adiposis dolorosa and fat redistribution, lymphedema, chronic venous insufficiency, plantar hyperkeratosis, cellulitis, skin infections, hidradenitis suppurativa, psoriasis, insulin resistance syndrome, and tophaceous gout.