Currently, women with missed abortion in the first trimester (anembryonic gestation or embryonic death) are offered expectant observation or surgical curettage, on the other side, vaginal misoprostol can be used as a medical therapy for these cases, that may provide a safe, rapid and effective medical method for evacuation of the uterus either alone or in combination with surgical evacuation according to the dose regimen and the response of the patients to the drug.