The general quality of mammography is often questioned. Contrast enhanced digital mammography and Digital Breast Tomosynthesis are two techniques that attempt to increase breast lesion conspicuity. Contrast-enhanced mammography enables visualization of tumors without inference from superimposed structures. It is based on the principle that rapidly growing tumors require increased supply of blood to support their growth. The contrast agent preferentially accumulates in such areas and contrast enhanced mammography offers a method of imaging the distribution of agent in the breast tissue. But it is still a 2D technique. Digital breast tomosynthesis is expected to overcome this limitation by providing slice images of the breast. It reduces overlap of breast tissue, particularly in dense breasts resulting in earlier breast cancer detection. The 3D analysis of the distribution of microcalcifications, or a 3D analysis concerning shape, margins and size of lesions, might be easier leading to a reduction of the recall rate of patients and fewer biopsies. Finally it may eliminate the need for multiple exposures of the same breast. From this review we concluded that: Contrast Enhanced Mammography and Digital Breast Tomosynthesis are superior to conventional and full field digital mammography in breast cancer detection and may supplant breast MRI.