Ocular neovascularization may affect the retina, choroid ,iris and cornea and is commonly seen in some of our most common sight-threatening eye diseases including diabetic retinopathy, age-related macular degeneration , retinopathy of prematurity (ROP) and ischemic retinal vein occlusions. The advent of (VEGF) treatments marks a major advancement in the treatment of those angiogenic eye diseases.