Background: Psoriasis is a common chronic inflammatory, immune-mediated skin disease and may cause significant quality of life impairment. Recent advances in the immunopathogenesis of psoriasis have broadened our understanding of psoriasis. Psoriasis is now considered a systemic immunoinflammatory condition, which may carry a risk of cardiovascular disease.Objective: To assess the cardiovascular risk profile of Egyptian patients with psoriasis compared to age and sex matched controls.Methods: BMI for 30 psoriasis patients, of various degrees of severity evaluated by PASI, and 30 age and sex matched controls was measured. Blood samples for estimation of serum lipids (cholesterol, TGs, LDL and HDL), homocysteine and hs-CRP were obtained from patients and controls. Cardiological assesment (clinical examination, ECG and Echo) and CT coronary calcium-scoring were performed for both groups.Results: There was significant increase in BMI, serum lipids, hs-CRP and homocysteine in psoriasis patients compared to controls. No ischemic changes were detected by ECG. Echo detected significant early diastolic dysfunction, systolic dysfunction and one patient was diagnosed for the first time to have DCM. No CAC was detected among psoriasis patients.Conclusion: According to our results, psoriasis is associated with metabolic syndrome and early systolic and diastolic dysfunction. Psoriasis patients, even with exclusion of known risk factors except obesity, may be at risk of atherosclerosis and CVD.