This study aims at registering the incidence of breast cancer cases were received by the pathology department in El Kaser El Aini Hospital, during the period from January 1, 2004 till December 31, 2008. During this period 472 female breast cancer cases were collected. The female breast cancer incidence found to be 22 % . Age ranged from 22 to 87 years. 390 cases (82.5 %) were invasive duct carcinoma, 42 cases (9%) were invasive lobular carcinoma, 9 cases (2%) were mixed type, 26 (5.5%) cases were duct carcinoma insitu, 4 (1%) cases were Paget's disease and 1 (0.2%) case was lobular carcinoma insitu. Statistically significant results were obtained.