One of the major causes of death is acute renal failure. The hemodialysis was the only way of treatment. The aim of our study was to evaluate the therapeutic value of mesenchymal stem cells and hepatocyte growth factor (HGF) as an alternative treatment and prediction of their mechanism of action through the measurement of TNF-α, IL-10 & VEGF. Our results showed that mesenchymal stem cells & HGF can be used effectively as a way of treatment.