This study reviews in brief the introduction into clinical practice ofopioids and non-opioids. This administration have achieved internationalpopularity in various clinical settings. The use of augmentation strategies(neuraxial opioids or non-opioids) in the epidural and intrathecal analgesia and peripheral nerve blockade and ganglion blockade is wide spread and increasing for the marginal of intraoperative pain, postoperative pain, labour pain, chronic non malignant pain and cancer pain (using implantable, programmable intrathecal pump).