Identification of patients at risk of postoperative complications could have an impact on the indications for a procedure as well as permitting modifications of treatment to reduce the surgical risk.Role of cytokines in patients having operation is still not completely understood. Some investigator have reported that the presence of postoperative high concentration or persisted high concentration of interleukin-6 (1L-6) and tumor necrosis factor alpha (TNF-α) are associated with high mortality. C-reactive protein may be used as a marker of severity of injury. Liver is warranted because evidence indicate that hepatic functional deterioration contribute to clinic morbidity due to its synthesis of acute phase protein and its high ability to synthesize urea.Aim of work was to evaluate the correlation between perioperative acute phase response and outcome of hepatic resection.This study was conducted on thirty hamsters. They were divided in three groups: control group, skin wound infection group and bone fracture group. All were exposed to hepatic resection. Blood samples were taken perioperative to estimate levels of some acute phase response proteins and to study their relations to postoperative morbidity and mortality.High preoperative acute phase proteins lead to higher morbidity and mortality in post operative period. Therapeutic intervention with anti cytokines may be helpful in decreasing these postoperative complications.