Introduction: Cirrhosis is the end result of chronic liver injury from avariety of causes. It is well recognized in many studies that complicatedliver cirrhosis is accompanied by hyponatremia . Aim of the Work: Theaim of the present work is to study the association between serum sodiumlevel and the severity of complications in liver cirrhosis. Subjects andMethods: Two hundred patients with complicated liver cirrhosis will berandomly selected from Internal Medicine department and classifiedaccording to Child-Pugh class and one hundred uncomplicated livercirrhosis individuals served as a control, Patients with hepatocellularcarcinoma presented at admission and during the follow up, also patientsusing diuretics within 1 month before admission or taking antiviral drugswere exluded. Results: Assessing the serum level among the two groupsrevealed a highly significant difference between the two studied groupsand a significant positive correlation was observed between serumsodium level and Child-Pugh score ,abdominal ascites, pl.effusion,hepaticencephalopathy and SBP, however, no correlation was detected betweenserum sodium level and HRS, esophegeal varices ,fundal varices ordevelopment of infection. Conclusion: There is conclusive evidence thatHyponatremia, especially serum levels <130 mmol/L, may indicate theexistence of severe complications associated with liver cirrhosis esp.ascites, pl.effusion and SBP.