Staphylococcus aureus (S. aureus) and methicillin resistant S. aureus (MRSA) are one of the leading causes of infections among burn patients. Methods: Burn sites of 400 patients were swabbed and cultured on conventional culture media. MRSA isolates were identified using ORSAB and RT-PCR. Results: S.aureus (40%) and MRSA (26%) are the most organisms infect burn wound. Conclusion: every burn institution should determine the specific pattern of burn wound microbial colonization, and the antimicrobial sensitivity profiles, improving the overall infection-related morbidity and mortality.