Human Rhinovirus infection in the expression of asthma-related symptoms. The study was conducted on 40 children aged 6 to 14 years, were classified into two groups: (group A: first time wheezers =11 patients) and (group B: chronic known asthmatics presenting with acute exacerbation =29 patients). In addition to 20 healthy age matched control. All subjects were subjected to a complete history and clinical study, and were investigated with emphasis on CBC with differential, CRP and total serum IgE. Chest X-ray was done to all subjects. Nasopharyngeal swabs were obtained from all subjects and the presence of Human Rhinovirus was determined by PCR examination. The results as regards absolute eosinophilic count (AEC) and IgE were significantly higher in patients than controls (p value=<0.001) in both groups. Positive PCR for Rhinovirus was detected in 1 (9%) in (group A= first time wheezers) and in 2 (6.8%) in {group B= known asthmatics during acute exacerbation). In conclusion, the present study does not support that rhinovirus infection might promote first attack wheezing or acute exacerbation of known asthma.