Sodium fluoride is used in dental products, insecticides, detergents production and in fluoridation of the drinking water. This study was carried out to throw more light on the adverse toxic effect of sodium fluoride on the ovary of adult albino rat and the possible protective role of vitamin C using light microscope. Thirty adult albino rats were used in the this study, divided into three groups, ten being the control group (A), group (B) received sodium fluoride and group (C) received sodium fluoride and vitamin C. Administration of sodium fluoride revealed ovarian follicles with degenerated granulosa as well as Cumulus oophorus cells. The oocytes were distorted and necrosed. Areas of hemorrhage and infiltration of inflammatory and fat cells were observed. On the other hand, concomitant administration of vitamin C and sodium fluoride resulted in reduction of the histological changes in the ovaries induced by fluoride administration.