The development of vaccines capable of preventing swine and other possible hosts from becoming infected with T. spiralis would make a substantial contribution towards the ultimate goal of disease elimination. The aim of this study is to compare the protective effects of crude larval extract vaccine and irradiated larval vaccine as regards immunization against trichinellosis. Study design: A prospective randomized controlled study including four groups of mice; (group A: immunized with irradiated larval vaccine; group B; immunized with crude larval extract; group C; non-immunized adjuvant group; group D: non-immunized infected control group). Animals will be examined for the adult and larval burden as well as for the humoral response against challenge infection. Results: Among the immunized groups there was a statistically significant lower adult worm count at the 7th day following challenge infection as well as reduced larval muscle count at the days 30 and 45 following challenge infection in comparison to the non-immunized control groups. There was a significantly higher serum antibody response and higher lymphocytes proliferative response among the immunized groups in comparison to the non-immunized groups. The protective effect was better among the group of mice immunized with crude larval extract antigen in terms of reduced adult worm and larval burden as well as humoral and cell mediated immune responses. Conclusion: immunization against trichinellosis using crude larval extract and irradiated larval vaccine is effective and could be useful for protection of different T. spiralis hosts in particular swine and this could provide hope in the disease elimination.