Aim of work: To compare the value of first trimester three-dimensional placental volume and second trimester uterine artery in predicting pregnancy-induced hypertension. Patients and methods: Our study included 100 pregnant women (50 high risk and 50 control group). They were subjected to measurement of placental volume at their first trimester (11- 13 weeks) and blood flow indices assessment of the uterine artery at second trimester (20-22 weeks). Results: Negative correlation between placental volume and uterine blood flow indices. Positive correlation between placental volume and VI, FI and VFI in prediction of preeclampsia. Conclusion: Placental volume measurement between 11-13 weeks is sensitive to predict preeclampsia as a first trimester screening test. So it has the advantage of early start of prophylactic treatment.