This work was a cross sectional study including (50) infants and children all presenting with wheezy chest recruited from the Pediatrics Pulmonology Outpatient Clinic, Specialized New Children Hospital (Abou El- Reesh), Cairo University. The patients’ mean age was 31.3 ± 20.9 (in months) , 70% were males and 30% were females. The aim is to study the frequency of hMPV in infants and children with wheezy chest and to demonstrate its correlation with the severity of the disease. All patients were classified into new onset wheezers and recurrent wheezers. Patients were re-classified our wheezy infants and children according to their atopic status into atopic 42% and non- atopic 58% groups. The hMPV was found in 6% (no=3) of the patients using direct immunoflorecense assay.