Objective: Rheumatoid arthritis is a common problem worldwide treated by combination of Non Steroidal Anti inflammatory Drugs (NSAIDs), Glucocorticoids and Disease-modifying antirheumatic drugs (DMARDs). The aim of this study is to determine the early OCT findings in preclinical chloroquine (CQ) retinopathy. Study design: A cross sectional comparative study. Place and duration: This study was conducted in Ophthalmology and Rheumatology Clinics, Kasr Al-Ainy Hospital, Cairo University; from July 2012 to August 2013. Patients and methods: Forty eyes of rheumatoid arthritis patients treated with chloroquine for more than one year and other fourty eyes of normal age matched individuals, all were subjected to full ophthalmological examination, colour vision testing with Ishihara Pseudoisochromatic Plates and imaging with Spectral Domain Optical Coherance Tomography (SD-OCT). The entire study group aged from 40 to 60 years old with normal fundus. Results: Outer retinal thinning in the form of foveal and parafoveal thinning was detected by SD-OCT in patients on chronic chloroquine use with still normal fundus. No inner retinal affection was detected as GCC and RNFL were within normal thickness. IS/OS junction was interrupted in only four rheumatoid patients (10%). Colour vision was affected only in six rheumatoid patients (15%). Conclusion: Screening of RA patients by SD-OCT can detect preclinical chloroquine retinopathy and this could be used as a screening technique especially with the increased availability of SD-OCT machines in most of ophthalmology centers.