Background: The role of inflammation in the pathogenesis and the course of epilepsy now is emerging however the exact mechanism is still unknown. Objectives: to measure levels of interleukin-6 (IL-6) in focal epilepsy temporal or extra-temporal and to assess the influence of epilepsy type , frequency and duration on serum levels of IL-6 in order to evaluate the possible role of inflammation and inflammatory mediators in focal epilepsy specially temporal lobe epilepsy. Subjects and methods: the study was conducted on 30 patients with TLE, 30 patients with extra TLE and 20 healthy control subjects. All patients were assessed using clinical evaluation, conventional digital EEG, brain MRI, routine labs and interleukin-6 level in serum. Results: Serum IL-6 level is significantly higher in patients with TLE than in patients with extra-TLE and there is a significant correlation between IL-6 level and the frequency and duration of seizures. Conclusion: There is a significant association between serum interleukin-6 level and type of focal epilepsy, frequency of seizures, and duration of seizure