Introduction: In recent years, antibiotic resistance has increased worldwide. The amount of antibiotics consumed in a community is directly related to the amount of antibiotic resistance found in that community. Although most of patients seen for acute bronchitis receive antibiotics, published trials demonstrated no clinically important benefit. The aim of this work: was to guide antibiotic prescription by clinical data and simple basic laboratory measures.Patients and methodology: A simple study was performed at General Outpatient Clinics of New Children Hospital - Cairo University, during a period of 5 months starting from the first of November – 2008 till the end of March – 2009. It included 100 patients. Their age ranged from 3 months to 12 years. All cases were subjected to full history taking, general examination, local examination and simple basic laboratory measures including CBC, ESR, and CRP. Blood culture (was carried out for cases with high grade fever only (≥39°C)). Results: males were more prevalent than females (56% versus 44%). Cough was a cardinal symptom in the current study and it was present in all cases.28% had productive cough. Toxic facies, anorexia and emesis were constituents of infections in 60 % of cases. Conjunctivitis was elicited in 10 % of cases; most of them were preschool children. 28 %of the study group presented with upper respiratory tract manifestations. Among the studied cases 80 % were anemic, while 6% had leucocytosis that was not statistically significant.3 % had bandemia. Lymphocytosis was present in 52 % of cases. In the current research only 2 cases had positive CRP and both are among the infant age group. Although ESR was elevated in 98% of cases, this increase was not statistically significant. In the current study there was significant correlation between bandemia and fever grade (P < 0.001). Also there was significant correlation between leucocytic count and some clinical variables as presence of secretions on local examination of the chest (P < 0.05) and toxic facies on general examination (P < 0.05). Conclusion: acute bronchitis in children is usually a self limiting disease and doesn’t require antibiotic as a routine medication.