Intracytoplasmic sperm injection (ICSI ) is now accepted as the treatmentof choice for severe male infertility in many centers around the world .This study contaning 80 cases and comparing them with 40 controls fromthe medical , genetic and neuro developmental point of view using theThe Denver Developmental Screening Test (DDST), commonly known asthe Denver Scale,Which is the most widely used test and has beenstandardized in 15 different countries for screening developmentalproblems in children.