Cardiac morbidity and mortality are closely related to cardiac volumes and global left ventricular (LV) function, expressed as left ventricular ejection fraction. Accurate assessment of these parameters is required for the prediction of prognosis in individual patients as well as in entire cohorts.The current standard reference for left ventricular function assessment is the analysis by short-axis magnetic resonance imaging. In recent years, major extensive technological improvements have been achieved in computed tomography. The most marked development has been the introduction of the multidetector CT (MDCT), which has significantly improved temporal and spatial resolutions.In order to assess the current status of MDCT for analysis of LV function, the current study on this subject was done. The data presented in this study indicate that the global left ventricular functional parameters measured by contemporary multi-detector row systems combined with adequate reconstruction algorithms and post-processing tools show a narrow diagnostic window and are interchangeable with those obtained by MRI.This study also compared between role of MDCT in analysis of LV function and other reference modalities such as trans-thoracic echo (TTE), SPECT, MRI and invasive techniques as cine ventriculography (CVG).