Disturbance in the antioxidant system could play a role in pathogenesis of chronic liver disease. The aim of the study was to evaluate the serum selenium concentration in 20 patients withcompensated liver disease, 20 patients, with decompensated liver disease and 10 patients with hepatocellular carcinoma. The result were compared with 20 health controls. Results: there was significant decrease in serum selenium level in hepatocellular carcinoma group morethan decompensated group more than compensated group when comparedto control group (p<0.01) . There was a highly significant positive correlation between serum selenium level and ast, total bilirubin, alkaline phosphatase in the diseased group. No significant relationship between serum selenium level and age of patients wereobserved. Conclusion: our study suggested the possible important protective role of selenium in patients with liver cirrhosis and also in patients with hepatocellular carcinoma, as well as the potential need of selenium supplemenetation in these patients