Introduction: Hepatocellular carcinoma is the 5th most common tumor and the most common primary liver tumor. In Egypt HCC is usually associated with liver cirrhosis and chronic viral hepatitis (HBV & HCV).Alpha Feto Protein (AFP) is glycoprotein. Serum level of AFP rises in primary malignant tumors of the liver and in some liver conditions as liver cirrhosis and hepatitis .Aim of the work: The aim of the work is to detect if there is a realation between the malignant tumor of the liver (HCC ) studied by Ultrasound and Color Doppler to serum level of AlphaFeto-protein (AFP). Subjects and methods; The study was done on 30 patients, using Ultrasound, Color Doppler, Power doppler, Fine needle Aspiration Cytology (FNAC) and Serum level of Alpha Feto-protein (AFP).Results: Hepatocellular carcinoma (HCC), is a hypervascular tumor .It was studied by Ultrasound and Color Doppler, where it had a peripheral and central vasculature , there is high flow (portal ) at the periphery and low flow ( arterial ) at the center of the lesion.. There was no relation between (HCC) and and serum level of AFP.Conclusion: Ultrasonography is an excellent non invasive , inexpensive and reproducible tool in predicting the nature of hepatic nodules, the presence of a halo on grey scale US, the presence of vascular supply that is mainly arterial or mixed on CDUS and Power DUS are all useful to distinguish between true HCC and malignant dysplastic nodules. Key words:- {Hepatocellular carcinoma ( HCC) , Ultrasound and Color Doppler, Alpha Fetoprotein (AFP) , Fine Needle Aspiration Cytology (FNAC)}