The present study showed high sensitivity for AMACR(87.5%) and specificity (81.25 %) and AMACR was found to behighly effective in differentiating prostatic carcinoma from benignprostatic glands as there was a statistically highly significantdifference between AMACR expression in carcinoma and benignglands(p<0.001).AMACR was expressed in different Gleason scores withoutpredilection for a certain Gleason score and there was no statisticalrelation between the Gleason score and AMACRimmunoreactivity. This study also showed no statistical relationbetween AMACR positivity and the different stages of the radicalprostatectomy specimens.The use of both AMACR and p63 was found to be useful inresolving 10 cases of ASL present in this study, 8 cases werepositive for p63 and negative for AMACR so they were diagnosedas benign lesions and 2 cases were negative for p63 and positivefor AMACR so they were diagnosed as small focus of prostaticcarcinoma.