Depression and anxiety are highly prevalent among medical students. Medical students are susceptible to high rates of morbidity during their undergraduate years and this can be related to impairment in the development of professional, academic, and social skills. Objective: To estimate the prevalence of anxiety, depression and their related factors among students at Faculty of Medicine, Cairo University and to assess the relationship between anxiety, depression and quality of life among the same group. Subjects and methods: This study is a cross sectional descriptive study in which 600 students were equivalently withdrawn from all scholastic years of Faculty of Medicine, Cairo University. Students included in this study were subjected to a structured self administered questionnaire, Social score sheet, Beck Anxiety Inventory, State-Trait Anxiety Inventory, Beck Depression Inventory and Heath related quality of life SF-36 measurement model. Results: Males represented 49.2 % of the studied group and females represent 50.8 %. The prevalence of anxiety was 36.8% and depression was 54.3% among the medical students. Co morbid depression and moderate to severe anxiety reached 27.8%. A gender difference was also reported, where female students were found to have a significantly higher level of depression and anxiety (59.5 % and 66.1 % respectively) versus males (40.5 % and 33.9 % respectively). Among the depressed and moderate to severe anxious students a significantly bigger proportion suffered from family problems (16.6% and 16.3% respectively) as compared to non depressed and low anxious group. Depressed and anxious students had significant financial problems. Financial difficulties were significantly reported by 31.0 % of the depressed stu¬dents versus 23.7% of the non depressed and 37.1% of the anxious students versus 22.2 % of the non anxious group. Conclusion: This study suggests that there are certain contributing factors beside academic stressors which predispose a medical student to psychological morbidity such as anxiety and depression. Recommendations: Medical students need psychological support for early detection and management of anxiety and depression. Key words: anxiety disorders - education - medical - depressive disorders/ etiology - sex factors - students - medical - quality of life - cross-sectional study.