Background: Psoriasis is considered a skin disorder, which primarily involves hyperproliferation of basal cells, resulting in an increased turnover of the tissue and truncation of cell maturation. Although the multi-factorial etiology of psoriasis is well established, family, and twin studies indicate a strong genetic component. Filaggrin is multifunctional protein known to play an important role during cornification. The genes encoding this protein are characterized by multiple tandem repeats of specific peptide motifs.Aim: This study was conducted to assess the association of filaggrin R501X and 2282del4 mutations with psoriasis and to estimate the level of filaggrin quantitatively.Patient and method: Thirty psoriasis patients and twenty control subjects were included in this study. Results: The association between these mutations and psoriasis was not significant. However mean filaggrin levels were significantly higher in control skin than both lesional and non lesional skin of patients.Conclusion: From the present study, it seems that the filaggrin R501X and 2282del4 mutations, in Egyptians (like Europeans) are not associated with higher risk of psoriasis development, although, the cutaneous FLG level was reduced in lesional skin of patients in comparison to non lesional skin of patients and controls.