Thalassemia, the most common genetic disorder in Egypt, is a major health problem with an estimated carrier rate of 5.3%-9%. Registered cases in large centers in Egypt in September 2007 were 9912 cases, and in Cairo University hematology clinic were 2597 cases. Hepcidin, a 25 amino-acid peptide hormone synthesized in the liver is the key regulator of iron homeostasis. We measured the level of hepcidin in congenital chronic hemolytic anemias including sickle cell anemia, hereditary spherocytosis, thalassemia syndromes. This study revealed the decrease of hepcidin level in all congenital chronic hemolytic anemias in comparison to control. The use of hepcidin as an adjuvant therapy with oral iron chelators is important as it has a vital role in combating hemosidrosis