Introduction: Quality of life in parents of children with chronic kidney disease is affected according to the degree of disease &method of treatement. Methods : This study include 75 patients 1-16 years old in 3 groups:group 1 include 40 child on regular HD, group 2 include 20 child on conservative therapy,group 3 include 15 child post transplantation in (Abou Elrish Children Hospital ,Cairo University) , HRQoL was assessed by questionnaire that was filled by parents attended with the childs usually the mother this included: social, physical, cognitive, communications, worry, family relationships, emotional & daily activities. Results: There was significant positive correlations between QOL(worry) and chronic maternal illness (P value=0.037) , between emotional functioning and paternal chronic illness (Pvalue=0.040).The higher frequency of visiting hospital the lower social functioning (p value=0.001), emotional functioning (p value=0.039), cognitive functioning (p value=0.017), family relationships (p value=0.000). Increase duration of the disease associated with decrease the daily activities (p value=0.046) and the communications (p value=0.011). Emotional functioning affected with maternal marital status (p value=0.021) Conclusion: Quality of life in parents of children with chronic kidney diseases highly affected by their childs illness in its all aspects . The worest QOLwas that of parents of patients on regular hemodialysis, The average was that on conservative therapy, the least affected is that of post transplantation patients.