FNA is widely used for evaluating palpable breast masses, breast cysts, and even non-palpable mammographic abnormalities. The use of FNA significantly decreases health care costs. This is a retrospective statistical study of F.N.A.C. of breast done in both cytology and histopathology units in pathology department of Kasr Al-Aini hospital, Faculty of Medicine, Cairo University between January 2006 and December 2010. FNAC findings were correlated with data from histopathology records to determine the reliability of FNAC. The aim of this work is to detect sensitivity, specificity and accuracy of cytopathology in diagnosis of breast malignancy. The total number of patients was 463, all were females ranging in age from 13 to 84 years with mean age of (44.27±12.928) years. About half of the cases (52.3%) were included in the age category (>40-60) and most of the cases (93.3 %) were aspirated in our department.