Background: SNPs are single-base inheritable variations in a given and defined genetic location that occur in at least 1% of the population. Analysis of DNA sequences shows considerable variability between individuals. The opportunity to rapidly detect unique SNPs and other DNA point mutations offers potential for developing personalized medicines with an advantage of early HCC diagnosis and treatment.Aim of The Work: This study was designed to assess the SNP analysis of IL1B and OAS in patients with HCV related end stage liver diseases (liver cirrhosis and HCC) to assess the ability to be used for early prediction of HCC.Methods: Whole blood samples were obtained from 25 HCC patients, 25 HCV-related liver cirrhosis in addition to 25 HBV & HCV seronegative controls. Routine clinical, laboratory and ultrasonographic assessments were done. HCC was diagnosed according to AASLD guidelines. SNP analysis was assessed by DNA specific restriction enzymes polymorphism.Results: SNP analysis of IL1B and OAS genes was detected with different frequencies in the HCV related CLD including HCC and also in control group with significant difference between the studied groups. Concluson: SNP analysis of IL-1 B and OAS can be used as molecular markers for early diagnosis of hepatocellular carcinoma in HCV related chronic liver diseases.