Aim: Is to assess level of P-selectin in pregnant females with DVT compared with a control group of pregnant females without DVT, and assessing its statistical significance if it is high, hence proving or disproving its potential role in the pathogenesis of DVT during pregnancy. Subjects and methods: We will test our hypothesis by measuring soluble P-selectin in the plasma of 20 pregnant women complicated with DVT and 20 pregnant women not suffering from DVT as a control in age group from 20-40 years old. Venous blood will be obtained from an anticubital vein, and citrated plasma will be collected after centrifugation. Patient and control samples will be treated the same. We will blind samples by coding them before laboratory analyses. We will measure s P-selectin by means of a highly sensitive sandwich ELISA technique and a commercially available test reagent set.Results: Our study showed that there is a significant increase in the P-selectin level in patients with DVT in pregnancy when compared to pregnant cases with no DVT. Our statistical analysis showed cutoff level of P-selectin in predicting DVT (= or >124) with accuracy 100%.