Aim: In this work we aimed to find a way to induce spermatogenisis in thosematuration arrest TESE negative normogonadotropic cases.Patients and Methods: twenty one azoospermic men were included in this studyAll the patients of them were recruited from Adam international hospital who areprimary infertile due to NOA with normal LH & FSH level, about 200 files ofpatients with non obstructive azoospermia were reviewed 40 of them werediagnosed of spermatogenic arrest with negative 1st TESE but only 21 cases wereable to continue the treatment regimen.Results: After taking a hormonal treatment (HCG and HMG) of at least 6 monthsand reaching in some cases up to one year, a semen analysis was done and 9 werefound producing sperms at the ejaculate, in which only 2 cases had usable spermsfor ICSI.A second TESE was done to the other 19 cases, with positive results for sperms in7 cases (representing 36.8%) including the 5 cases previously showing sperms attheir ejaculate, as well as the 2 cases not previously showing sperms at theejaculate.The operation showed no sperms in the remaining 12 cases (representing 63.2%)(That included 2 previously showing sperms at the ejaculate and 10 not previouslyshowing sperm in their ejaculate).Conclusion: long term gonadotropin treatment has an unmistakable impact onnormogonadotropic patients with maturation arrest.