Introduction: Hepatitis C is a common infection in the Egyptianpopulation, specially genotype 4. It is well recognized in many studiesthat hepatitis C chronic infection is associated with hypolipidemia. Aimof the Work: The aim of the present work is to study the relationbetween hepatitis C virus infection and Child-Pugh classification andcirculating lipids level including apolipoprotein B. Subjects andMethods: Sixty patients with chronic hepatitis C infection will berandomly selected from Internal Medicine department and classifiedaccording to Child-Pugh class after informed consent and sixty healthyage and sex matched individuals served as a control. Patients withhepatitis B infection, diabetic patients and those with history ofdyslipidemia or on medications for dyslipidemia were excluded.Results: Assessing the lipid profile among the two groups revealed ahighly significant difference between the two studied groups and asignificant negative correlation was observed between Child-Pugh scoreand Cholesterol, HDL and LDL, however, no correlation was detectedbetween TG and ApoB. Conclusion: There is conclusive evidence thatthe production of infectious virus from HCV-infected cells relies onseveral aspects of lipid metabolism.