Dendritic cells (DCs) which are derived from bone marrow progenitor cells serve as antigen presenting cells that play a major role in the initiation and maintenance of innate and adaptive immunity.Hepatitis C virus remains prevalent in patient receiving regular dialysis all over the world. It appears that the hemodialysis (HD) procedure per se can preserve patient from an aggressive course of HCV by reducing the virus load.The study aimed to assess the dendritic cells functions in HCV infected patients on hemodialysis via analysis of co-stimulatory markers (CD83, CD86 and CD40), a co-inhibitory marker (PDL-1) in blood mononuclear cells and also to assess serum hyaluronic acid and IL-10 levels to correlate their levels with dendritic cells markers. This study was conducted on 2 groups: group 1 involved 50 HCV uremic patients on hemodialysis; group 2 involved 24 control subjects. Results showed that there was a significant decrease in DCs co-stimulatory markers in HCV infected hemodialysis patient. There was a significant increase in DCs co-inhibitory marker in HCV infected hemodialysis patient. There was a significant increase in serum hyaluronic acid and IL-10 levels in HCV infected hemodialysis patient. Moreover, there was a significant inverse correlation between IL-10 and CD40, whereas, there was a significant positive correlation between IL-10 and PDL-1 in HCV uremic patients.