Despite that bisphenol A (BPA) was widely used in industry, it can exert a number oftoxicological effects on tissues mainly the endocrine system through its estrogenicaction. Aim: the aim of the study was to evaluate the possible endocrinal dysfunctionamong BPA exposed workers with special emphasis on metabolic and sex hormonesaffects. Results: this study shows an elevation in urinary BPA level among workersas well as an increased follicle stimulating hormone (FSH), leutinizing hormone (LH),insulin, fasting blood sugar and post prandial blood sugar levels. Also, the resultsshow that the prevalence of type 2 diabetes mellitus and insulin resistance was higherin the exposed group with positive correlation with the urinary BPA level.Conclusion: Occupational exposure to BPA can exert substantial adverse effects onendocrine system. Bisphenol A affects pituitary secretion of both FSH and LH andconsequently causes alterations in male reproductive axis and hormonal secretion.Also, exposure to BPA increases the risk of developing insulin resistance and type 2diabetes mellitus.