Background: Breast cancer is a major public health burden throughout the world. It is the most frequent cancer among women all over the world, In Egypt; breast cancer ranked the 1st among all cancers constituting 38.5% of all female cancers. Despite the common occurrence, the exact etiology of breast cancer is still unknown. It is believed that breast cancer is a multifactorial disease and it is a result of the interaction of genetic and environmental factors. Also epidemiologic data suggest that the mammographic breast density is a strong predictor of breast cancer.Aim: The present study aims to identify prevention strategy to decrease incidence of breast cancer among Egyptian femalesSubjects and methods: The study is a hospital-based cross-sectional study in which 500 females (249 malignant and 251 non malignant) attending in mammography unit at radiology department, at National Cancer Institute, Cairo University were included. All subjects had a mammogram and answered a questionnaire and (100) females gave blood sample for blood lipid test.Results: Nutritional habits have an influence on risk of breast cancer, intake of fruits and vegetables were significantly higher in the nonmalignant group (p<0.001 and =0.003 respectively), also dairy products intake (milk, cheese and yoghurt) were significantly higher in the non malignant group with (p=0.001, 0.002 and<0.001) respectively, while the malignant group consumes more servings of fried food per week p <0.001. Physical activity in terms of MET minutes/week showed significantly higher activity in nonmalignant group, p=0.003. The blood lipid profile showed that the malignant group had significantly higher levels of cholesterol and triglycerides than the nonmalignant group (p = 0.030 and 0.050, respectively). Mammographic breast density was associated with increased risk of breast cancer, risk showed to be more than double 2.36 in those with 50-75% dense tissue ,while the risk became more than four times if mammogram showed >75% dense breast( OR=4.27.95%CI:2.31-7.9). Results of logistic regression showed that, obese women BMI (≥30) are 13% at higher risk of developing breast cancer compared to those with BMI <30 ,OR=1.13(1.09-1.18), p <0.001.age at menarche also raises the likelihood of cancer 9 times (OR=9.76.95%CI: 4.77-19.96) if it is less than 14 years.Conclusion: Healthy life style, physical exercise, normal BMI, diet rich in fruits and vegetables and less of fried food are protective factors of breast cancer, also females with high mammographic breast density should apply for regular mammogram.