Hepatitis C related ESLD is the main indication for liver transplantation and represents 89.8% of cases in Egypt. The influence of HCV infection on allograft histology is highly variable with several factors have been suggested that may accelerate HCV reinfection of the allograft.It was found that any genetic variants that affect OAS1 activity could be important determinants of susceptibility/resistance to antiviral treatment and to virus-related disease progression. IL28B single nucleotide polymorphisms (SNPs) play important roles in the management of hepatitis C virus (HCV) infections and are strongly associated with spontaneous and treatment-induced HCV clearance.The aim of this study was to evaluate the 2',5'-Oligoadenylate Synthetase (OAS), Interleukin 28B (IL28B), Interleukin 1B (IL1B) polymorphisms and their association with rate of recurrence of HCV following liver transplantation in patients with HCV infection.