The internal fixation of fractures has evolved in recent decades with a change of emphasis from mechanical to biological priorities. More flexible fixation should encourage the formation of callus while less precise, indirect reduction will reduce operative trauma. This approach is described as ‘biological internal fixation’. It involves the use of locked internal fixators which have minimal implant-to-bone contact, long-span bridging and fewer screws for fixation. Formerly, internal fixation with a plate aimed at absolute stability to avoid micromovement which could result in loosening of the implant and a delay in healing. The new technique of internal fixation, however, seems to tolerate and even require some degree of mobility of the interface of the fracture. Comparative study in biological fixation of fracture femur between Minimal Invasive percutaneous plating osteosynthesis and intramedullary nail.