Objective: The present study was done to determine cardiac valve affection in patients with systemic lupus erythematosus and the levels of anticardiolipin antibodies were measured and correlated with clinical activity, laboratory manifestations findings of the disease. Methods: 40 patients SLE patients were included in the present study. Anticardiolipin antibodies levels were measured in human serum using the ELISA technique. M-mode two dimensional and Doppler echocardiography was done to assess cardiac valve abnormalities. Disease activity was assessed using the SLE Disease Activity Index (SLEDAI). Results: Valvular abnormalities were detected in 22 patients (55%). The most frequent finding was mitral regurge (47.5%), while mitral stenosis was present in (22.5%). Aortic stenosis was present in (15%) and the same was the aortic regurge, tricuspid stenosis was present in (15%) of patients and tricuspid regurge was present in (22.5%) of patients. Fifteen SLE patients (42.5%) had increased IgG anticardiolipin antibodies, 18 SLE patients (45%) had increased IgM anticardiolipin antibodies. Valvular abnormalities were associated with positive anticardiolipin antibodies (p<0.01). Also a statistical significance between valve disease and disease activity was detected (P <0.01).Conclusion: We postulate a prominent role for anticardiolipin antibodies in the pathogenesis of heart valve disease in patients with SLE