Gestational trophoblastic disease (GTD) is the disease arises fromthe trophoblastic ectodermal layer of fertilized ovum is among therare human tumors that can be cured even in the presence of widespread dissemination. The World Health Organization has classified gestationaltrophoblastic disease (GTD) into two: (1) Premalignant termedcomplete hydatidiform mole (CM) and partial hydatidiform mole(PM) and three malignant disorder invasive mole, gestationalchoriocarcinoma and placental site trophoblastic tumors (WHO,1983). (2) These malignant disorder are also frequently referred to asgestational trophoblastic tumor (GTT) or persistent gestationaltrophoblastic disease (PGD).