Preeclampsia is a disease affecting pregnant women after 20 weeks ofgestation characterized by hypertension and proteinuria. Preeclampsiaremains a leading cause of maternal and fetal mortality and morbiditywhile research in this important area of reproductive disease remainssporadic and grossly undefended. Preeclampsia is a major cause of poorfetal outcome in pregnancy: as preterm infant, intrauterine growthrestriction (IUGR), neurological disease and cardiovascular diseases laterin life. Despite improvements in clinical management, preeclampsiausually results in induced delivery of a very preterm infant. While earlytermination protects the fetus from an intrauterine death, the newbornthen faces increased risks associated with preterm delivery. Preeclampsiacauses placental damage that result in uteroplacental insufficiency. Thepathogenic mechanism is thought to be a failure of trophoblastic invasionin maternal spiral arterioles at 20 to 22 weeks of gestation. This failurecauses luminal narrowing and medial degeneration, leading to diminishedblood flow to the developing infant. Consequently, these infants fail togrow normally. Intrauterine growth restriction (IUGR) carries anincreased risk of perinatal mortality and morbidity. Identification ofIUGR is crucial because proper evaluation and management can result ina favorable outcome