Fifty women were included into the statistical analysis and 26 (52%) of them developed pre-eclampsia during follow-up.This study revealed a cutoff level of homocysteine and leptin which are 8.44 and 96.4 ng/ml respectively above which pregnants are more prone to develop preeclampsia. The present study qualitatively showed a more positive association between homocysteine and preeclampsia (PE) (sensitivity: 95.8%, specificity: 100%) than between leptin and PE (sensitivity: 58.33%, specificity: 66.67%). Thus our study reveals that homocysteine is a more useful predictor marker than leptin in predicting preeclampsia