Background: Dyslipidemia is a significant CVD risk factor in persons with diabetes. CVD is the leading cause of death in people with T1DM. Objective: To evaluate the frequency, pattern and relations of dyslipidemia in children and adolescents with T1DM in DEMPU. Method: In this cross-sectional study, fasting lipid profile of 60 patients aged ≥ 9 years with T1DM was measured and compared with that of 39 healthy age and sex matched children. Results: Dyslipidemia was found in 65.0% of patients compared with 28.2% of the control group with a statistically significant difference (p< 0.001). Fifty percent of the patients had elevated LDL-C levels with a mean of 102.0 ± 34.4 mg/dl and a positive significant correlation with BMI. There were positive significant correlations between the dyslipidemia and female sex and activity. The most frequent type of dyslipidemia was high LDL-C and low HDL-C. Dyslipidemia was found regardless the family history, degree of glycemic control, BMI SDS, diabetes duration and dietary habits. Conclusion: Dyslipidemia in children and adolescents with T1DM was significantly more frequent than in healthy control subjects. So, screening and management may be considered especially in diabetic females. LDL-C is the ‘cornerstone’ for assessment of lipoprotein-related CVD risk. Activity is important for prevention of dyslipidemia.